Determinação quantitativa via RMN com Intensidade absoluta de Sinal.

Quantitative NMR using absolute sinal intensities.

Results shown

Usually qNMR relies on internal or external standards. The method shown here uses only the absolute signals intensity, which has to be calibrated once. With this we can vary the number of scans without problems, but not the reciever gain.

Literature cited

The following literature references are used for this poster:

  1. van Heeswijk, R.P.G.; Hoetelmans, R.M.W.; Meenhorst, P.L.; Mulder, J.W.; Beijnen J.H.; J. Chromatogr B 1998, 713, 395; Murphy, R.L.; Montaner, J.; Exp. Opin. Invest. Drugs 1996, 5, 1183.
  2. Langmann, P.; Schirmer, D.; Vath, T.; Desch, S.; Zilly, M.; Klinker H.; J. Chromatogr B 2002, 767, 69; Lopez, R.M.; Pou, L.; Gomez, M.R.; Ruiz, I.; Monterde, J.; J. Chromatogr B 2001, 751, 371; Hollanders, R.M.F.; Kolmer, E.W.J.V.; Burger, D.M.; Wuis, E.W.; Koopmans, P.P.; Hekster, Y.A.; J. Chromatogr B 2000, 744, 65; Pav, J.W.; Rowland, L.S.; Korpalski, D.J.; J. Pharm. Biomed. Anal. 1999, 20, 91.
  3. Kaul, N.; Agrawal, H.; Paradkar, A.R.; Mahadik, K.R.; Talanta, 2004, 62, 843; Sarkar, M.; Khandavilli, S.; Panchagnula, R.; J. Chromatogr B 2006, 830, 349; Sekar, R.; Azhaguvel, S.; Chromatographia 2008, 67, 389.
  4. Robins, M.J.; Sarker, S.; Wnuk, S.F.; Nucleos Nucleot 1998, 17, 785-790; Malz, F.; Jancke, H.; J Pharmaceut Biomed 2005, 38, 813-823.
The Poster

Poster