Desenvolvimento de novos potenciais fármacos para a quimioterapia de doenças causadas por micobatérias.
Development of new molecules with activity against deseases caused by mycobacteriae.
The poster shows the synthetic path suggested for the synthesis of the skeleton of a natural product that showed activity against mycobacteriae. The skeleton contains elements that will allow us to make further modifications, when trying to reproduce the activity. We hope to carry out the synthesis in six steps, each of which should be relatively simple.
The following literature references are used for this poster:
- Chen, Jih-Jung; Yang, Chang-Syun; Peng, Chien-Fang; Chen, Ih-Sheng; Miaw, Chang-Ling, J.Nat. Prod., 2008, 71(6), 1016-1021.
- Marshall, James A.; Pike, M. T.; J. Org. Chem.,1968,33,435.